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Alternative Hydrogen Source for Asymmetric Transfer Hydrogenation in the Reduction of Ketones
Author(s) -
Wakeham Russell J.,
Morris James A.,
Williams Jonathan M. J.
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500886
Subject(s) - transfer hydrogenation , ruthenium , noyori asymmetric hydrogenation , chemistry , catalysis , reduction (mathematics) , hydrogen , lactone , ketone , combinatorial chemistry , asymmetric hydrogenation , enantioselective synthesis , organic chemistry , geometry , mathematics
cis ‐1,4‐Butenediol is shown to be a highly active hydrogen source for asymmetric transfer hydrogenation in the reduction of ketones. With the use of a ruthenium catalyst, cis ‐1,4‐butenediol is isomerised and subsequently oxidised to a lactone as an irreversible step, which provides the driving force for the asymmetric reduction of ketones.