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Regioselective C−S Bond Formation between Flavones and Arylsulfonyl Chlorides through the Use of Ammonium Iodide
Author(s) -
Zhao Wannian,
Zhou Aihua
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500673
Subject(s) - regioselectivity , flavones , chemistry , iodide , thioether , ammonium iodide , catalysis , sulfonyl , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl , chromatography
A novel and regioselective ammonium iodide mediated C−S bond formation protocol involving flavones and sulfonyl chlorides to generate different ArS‐substituted flavone derivatives in high yields was developed. Different from existing metal‐free C−S bond formation protocols with the use of PPh 3 or I 2 as the catalyst, this method provides an alternative way of constructing C−S bonds through the use of NH 4 I as a catalyst, which makes it highly valuable for the efficient synthesis of thioether compounds.