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Advances in Pathway Engineering for Natural Product Biosynthesis
Author(s) -
Pearsall Sarah M.,
Rowley Christopher N.,
Berry Alan
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500602
Subject(s) - natural product , biochemical engineering , metabolic engineering , environmentally friendly , organic synthesis , synthetic biology , nanotechnology , chemistry , combinatorial chemistry , organic chemistry , computational biology , biology , materials science , engineering , catalysis , ecology , enzyme
Biocatalysts provide an efficient, inexpensive and environmentally friendly alternative to traditional organic synthesis, especially for compounds with complex stereochemistries. The past decade has seen a significant rise in the use of biocatalysts for the synthesis of compounds in an industrial setting; however, the incorporation of single enzymatically catalysed steps into organic synthesis schemes can be problematic. The emerging field of synthetic biology has sparked interest in the development of whole‐cell factories that can convert simple, common metabolites into complex, high‐value molecules with a range of applications such as pharmaceuticals and biofuels. This Review summarises conventional methods and recent advances in metabolic engineering of pathways in microorganisms for the synthesis of natural products.