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Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products
Author(s) -
Gurubrahamam Ramani,
Cheng YouSong,
Huang WanYun,
Chen Kwunmin
Publication year - 2016
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500455
Subject(s) - kinetic resolution , iminium , desymmetrization , organocatalysis , stereocenter , chemistry , carbene , catalysis , enamine , combinatorial chemistry , biocatalysis , enantioselective synthesis , organic chemistry , reaction mechanism
Abstract This Minireview describes organocatalytic kinetic resolution (OCKR) that has evolved on the basis of using small organic catalysts through enamine/iminium ion, N‐heterocyclic carbene, and hydrogen‐bonding catalysis. The review includes the use of recent methodologies for which the evolution of OCKR mainly involves creating new stereogenic center(s) in functionalized products through the formation of a C−C, C−N, C−O, C−X, or C−S bond. The combination of OCKR with sequential reactions and its association with desymmetrization and dynamic kinetic resolution are also described.