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Organocatalytic Enantioselective Aza‐Michael Reaction of Benzotriazole to β,β‐Disubstituted Nitroalkenes
Author(s) -
Chen ShengWei,
Zhang GuiCheng,
Lou QinXin,
Cui Wei,
Zhang ShaSha,
Hu WenHui,
Zhao JunLing
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500373
Subject(s) - enantioselective synthesis , stereocenter , bifunctional , benzotriazole , michael reaction , thiourea , chemistry , organocatalysis , catalysis , organic chemistry , combinatorial chemistry
An enantioselective aza‐Michael reaction of benzotriazole to β,β‐disubstituted nitroalkenes has been developed. This reaction was catalyzed efficiently by a bifunctional thiourea catalyst, affording the corresponding products, bearing quaternary stereogenic centers, in moderate to high yields (up to 80 %) and with high enantioselectivities of up to 95 % ee .