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Silver‐Catalyzed Synthesis of 1‐Chloroalkynes Directly from Terminal Alkynes
Author(s) -
Shi Dunfa,
Liu Zhiwen,
Zhang Ziyu,
Shi Wei,
Chen Hao
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500243
Subject(s) - catalysis , substrate (aquarium) , distillation , chemistry , salt (chemistry) , filtration (mathematics) , organic chemistry , reaction conditions , combinatorial chemistry , scope (computer science) , computer science , mathematics , statistics , oceanography , programming language , geology
An efficient method to prepare 1‐chloroalkynes was investigated. The method involved the use of readily available terminal alkynes and a catalytic amount of a silver salt with N ‐chlorosuccinimide as the chlorinating agent under mild conditions. Compared with the existing process, this method has a broad substrate scope: 19 examples were explored, and the products were obtained in excellent yields and were easily isolated by vacuum distillation. Moreover, recycling of the catalyst was achieved by simple filtration and desiccation, which made the method more economic and environmentally benign.