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para ‐Quinone Methide: a New Player in Asymmetric Catalysis
Author(s) -
Parra Alejandro,
Tortosa Mariola
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500176
Subject(s) - quinone methide , organocatalysis , enantioselective synthesis , chemistry , catalysis , quinone , malonate , combinatorial chemistry , organic chemistry
A new sheriff in town: para ‐Quinone methides ( p ‐QMs) have been successfully used in asymmetric organocatalysis. Particularly, the asymmetric 1,6‐addition of phenyl malonate and different aldehydes to 2,6‐disubstituted p ‐QMs has provided a rapid access to important chiral diarylmethines, highlighting the importance of these synthetic intermediates. These new structures will open up the development of important asymmetric transformations in the future.