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Palladium‐Catalyzed Oxidative Heck Coupling of Cyclic Enones with Simple Arenes by CH Activation
Author(s) -
Chung Leung Gulice Yiu,
Juwaini Nur Asyikin Binte,
Seayad Jayasree
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201500079
Subject(s) - palladium , chemistry , catalysis , heck reaction , oxidative coupling of methane , aryl , oxidative phosphorylation , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl , biochemistry
A simple catalyst system consisting of Pd(OAc) 2 and 3‐nitropyridine for the aerobic oxidative Heck coupling of cyclic enones, in particular challenging unsubstituted cyclic enones, with simple arenes by CH activation was investigated. This novel method was applied to various functionalized arenes and cyclic enones and allowed the synthesis of β‐aryl cyclic enones in modest to high yields.