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Inside Cover: Rhodium‐Catalyzed Decarbonylative Direct C2‐Arylation of Indoles with Aryl Carboxylic Acids (ChemCatChem 11/2014)
Author(s) -
Zhang Lingjuan,
Xue Xiao,
Xu Conghui,
Pan Yixiao,
Zhang Guang,
Xu Lijin,
Li Huanrong,
Shi Zhangjie
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201490063
Subject(s) - rhodium , decarbonylation , aryl , chemistry , catalysis , regioselectivity , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
The Rhodium Army Needs You! The cover picture shows an army of 2‐aryl indoles pouring from the foothills of the rhodium mountains. In their Communication on p. 3069 ff., L. Xu's group described a rhodium(I)‐catalyzed decarbonylative direct C2‐arylation of N ‐(2‐pyrimidyl)‐indoles with diversely substituted aryl carboxylic acids. The process produces 2‐aryl indoles in high yields with excellent regioselectivity and broad substrate scope. Mechanistic evidence supports that the reaction involves a decarbonylation step, and the carboxylic acids could be in situ activated by the treatment with ( t BuCO) 2 O to generate the active anhydrides.