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Pd/C‐Catalyzed Synthesis of Isoquinolones through CH Activation
Author(s) -
Shu Zhen,
Li Wei,
Wang Baiquan
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201403059
Subject(s) - catalysis , chemistry , ligand (biochemistry) , combinatorial chemistry , organic chemistry , biochemistry , receptor
The direct synthesis of isoquinolones from benzamides and alkynes through CH activation was developed by using Pd/C as a heterogeneous catalyst without a ligand under mild conditions. A variety of isoquinolones were obtained in good yields with excellent regioselectivities. The Pd/C catalyst could be recycled three times without a significant decrease in the activity (yields as high as 85 %).
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