A Cu II ‐N,P Oxazolinylferrocene Ligand Complex for the Asymmetric [3+2] 1,3‐Dipolar Cycloaddition of Azomethine Ylide with Malonates | Zendy

Dai Li | Zendy; Xu Di | Zendy; Tang LiWei | Zendy; Zhou ZhiMing | Zendy

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A Cu II ‐N,P Oxazolinylferrocene Ligand Complex for the Asymmetric [3+2] 1,3‐Dipolar Cycloaddition of Azomethine Ylide with Malonates

Author(s) -

Dai Li,

Xu Di,

Tang LiWei,

Zhou ZhiMing

Publication year - 2015

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201403048

Subject(s) - pyrrolidine , azomethine ylide , cycloaddition , chemistry , enantioselective synthesis , ligand (biochemistry) , ylide , 1,3 dipolar cycloaddition , medicinal chemistry , stereochemistry , catalysis , organic chemistry , receptor , biochemistry

A series of enantioselective pyrrolidine‐2,4,4‐tricarboxylate derivatives were synthesized by the [3+2] 1,3‐dipolar cycloaddition of azomethine ylide with alkylidene malonates. By using 4 mol % of a Cu II N,P oxazolinylferrocene ligand complex and 10 mol % of a base, pyrrolidine analogues were obtained in high yields (77–99 %) and excellent enantioselectivities (up to 99 % ee ).

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