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Synthesis of Oxazolidinones from Epoxides and Isocyanates Catalyzed by Rare‐Earth‐Metal Complexes
Author(s) -
Wang Peng,
Qin Jie,
Yuan Dan,
Wang Yaorong,
Yao Yingming
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201403015
Subject(s) - cycloaddition , chemistry , rare earth , catalysis , stereoselectivity , ligand (biochemistry) , metal , epoxide , combinatorial chemistry , organic chemistry , mineralogy , biochemistry , receptor
Rare‐earth‐metal complexes stabilized by an amino‐bridged triphenolate ligand showed high efficiency in catalyzing the cycloaddition of isocyanates and epoxides in the presence of NBu 4 I under mild conditions. This strategy is applicable to both terminal and disubstituted epoxides as well as various isocyanates, and tolerated different types of functional groups. Moreover, it is highly regio‐ and stereoselective, and afforded 3,5‐disubstituted oxazolidinones as the only products in most cases in moderate to good yields.