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Regioselective Direct Arylation of Fused 3‐Nitropyridines and Other Nitro‐Substituted Heteroarenes: The Multipurpose Nature of the Nitro Group as a Directing Group
Author(s) -
Iaroshenko Viktor O.,
Gevorgyan Ashot,
Mkrtchyan Satenik,
Grigoryan Tatevik,
Movsisyan Ester,
Villinger Alexander,
Langer Peter
Publication year - 2015
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201402715
Subject(s) - regioselectivity , nitro , chemistry , group (periodic table) , scope (computer science) , combinatorial chemistry , nitro compound , medicinal chemistry , stereochemistry , organic chemistry , catalysis , computer science , alkyl , programming language
Abstract We report Pd‐ and Ni‐catalysed, guided and regioselective CH arylations of a series of fused 3‐nitropyridines. The method described here is a facile tool for the chemical functionalisation of drug‐like fused pyridines. The scope and limitations of the reaction, the chemical potential of the nitro group and a putative reaction mechanism are discussed.