Regioselective Direct Arylation of Fused 3‐Nitropyridines and Other Nitro‐Substituted Heteroarenes: The Multipurpose Nature of the Nitro Group as a Directing Group | Zendy

Iaroshenko Viktor O. | Zendy; Gevorgyan Ashot | Zendy; Mkrtchyan Satenik | Zendy; Grigoryan Tatevik | Zendy; Movsisyan Ester | Zendy; Villinger Alexander | Zendy; Langer Peter | Zendy

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Regioselective Direct Arylation of Fused 3‐Nitropyridines and Other Nitro‐Substituted Heteroarenes: The Multipurpose Nature of the Nitro Group as a Directing Group

Author(s) -

Iaroshenko Viktor O.,

Gevorgyan Ashot,

Mkrtchyan Satenik,

Grigoryan Tatevik,

Movsisyan Ester,

Villinger Alexander,

Langer Peter

Publication year - 2015

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201402715

Subject(s) - regioselectivity , nitro , chemistry , group (periodic table) , scope (computer science) , combinatorial chemistry , nitro compound , medicinal chemistry , stereochemistry , organic chemistry , catalysis , computer science , alkyl , programming language

We report Pd‐ and Ni‐catalysed, guided and regioselective CH arylations of a series of fused 3‐nitropyridines. The method described here is a facile tool for the chemical functionalisation of drug‐like fused pyridines. The scope and limitations of the reaction, the chemical potential of the nitro group and a putative reaction mechanism are discussed.

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