Concurrent Cross Metathesis and Enzymatic Oxidation: Enabling Off‐Equilibrium Transformations | Zendy

Köhler Valentin | Zendy; Ward Thomas R. | Zendy

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Concurrent Cross Metathesis and Enzymatic Oxidation: Enabling Off‐Equilibrium Transformations

Author(s) -

Köhler Valentin,

Ward Thomas R.

Publication year - 2014

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201402150

Subject(s) - metathesis , biocatalysis , carbene , alkene , chemistry , catalysis , ruthenium , homogeneous , combinatorial chemistry , homogeneous catalysis , enzyme catalysis , organic chemistry , stereochemistry , reaction mechanism , polymerization , physics , thermodynamics , polymer

Criss‐cross catalysis: H. Zhao, J. F. Hartwig and co‐workers have combined homogeneous alkene metathesis and biocatalysis in a concurrent fashion. A ruthenium–N‐heterocyclic carbene (NHC) complex provides an equilibrating mixture of cross metathesis products. The selective simultaneous epoxidation by cytochrome P450 BM3 enables product yields well above the hypothetical two‐step process.

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