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Concurrent Cross Metathesis and Enzymatic Oxidation: Enabling Off‐Equilibrium Transformations
Author(s) -
Köhler Valentin,
Ward Thomas R.
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201402150
Subject(s) - metathesis , biocatalysis , carbene , alkene , chemistry , catalysis , ruthenium , homogeneous , combinatorial chemistry , homogeneous catalysis , enzyme catalysis , organic chemistry , stereochemistry , reaction mechanism , polymerization , physics , thermodynamics , polymer
Criss‐cross catalysis: H. Zhao, J. F. Hartwig and co‐workers have combined homogeneous alkene metathesis and biocatalysis in a concurrent fashion. A ruthenium–N‐heterocyclic carbene (NHC) complex provides an equilibrating mixture of cross metathesis products. The selective simultaneous epoxidation by cytochrome P450 BM3 enables product yields well above the hypothetical two‐step process.