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Palladium‐Catalyzed Silver‐Mediated α‐Arylation of Acetic Acid: A New Approach for the α‐Arylation of Carbonyl Compounds
Author(s) -
Wu GuoJie,
Guan Jing,
Han FuShe,
Zhao YuLong
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201402061
Subject(s) - acetic acid , catalysis , palladium , chemistry , phenylacetic acid , aryl , combinatorial chemistry , organic chemistry , alkyl
A new approach for the α‐arylation of acetic acid through Pd‐catalyzed silver‐mediated direct CH arylation of acetic acid with aryl iodides was developed. This protocol provided a straightforward method for the synthesis of a diverse set of α‐phenylacetic acids.