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Chemospecific Intramolecular Buchner Reaction Catalyzed by Copper(II) Acetylacetonate
Author(s) -
Mo Shanyan,
Xu Jiaxi
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201400014
Subject(s) - chemoselectivity , intramolecular force , catalysis , chemistry , copper , substrate (aquarium) , combinatorial chemistry , reaction conditions , scope (computer science) , organic chemistry , medicinal chemistry , computer science , oceanography , programming language , geology
A chemospecific intramolecular Buchner reaction of N ‐benzyl‐2‐cyano‐2‐diazoacetamides catalyzed by inexpensive copper(II) acetylacetonate (acac) has been achieved to synthesize a variety of 9‐aza‐1‐cyanobicyclo[5.3.0]deca‐2,4,6‐trien‐10‐ones, 5,7‐bicyclic products. The methodology involves sole chemoselectivity, an inexpensive metal catalyst, broad substrate scope, and moderate to excellent yields.