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Heterogenized Gold(I)–Carbene as a Single‐Site Catalyst in Continuous Flow
Author(s) -
Lothschütz Christian,
Szlachetko Jakub,
van Bokhoven Jeroen A.
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300997
Subject(s) - carbene , piperazine , catalysis , polystyrene , nucleophile , chemistry , polymer chemistry , metal , oxidation state , continuous flow , combinatorial chemistry , photochemistry , organic chemistry , polymer , physics , mechanics
Catalytically active gold(I)–carbene complexes on a polystyrene backbone were synthesized by treating metal‐coordinated isocyanides with the nitrogen nucleophile of a piperazine group bonded to the polystyrene. The local environment of the metal was readily tuned by variation of the functional group. This versatile synthesis procedure is not restricted to gold and can easily be extended to other metals such as Pd and Pt. The gold carbene complexes were extensively characterized, and resonant inelastic X‐ray scattering identified the +1 oxidation state of the supported gold. This single‐site catalyst catalyzed the synthesis of oxazoles, and the system could be used in continuous flow.