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Monoamine Oxidase–ω‐Transaminase Cascade for the Deracemisation and Dealkylation of Amines
Author(s) -
O'Reilly Elaine,
Iglesias Cesar,
Turner Nicholas J.
Publication year - 2014
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300990
Subject(s) - enantiopure drug , chemistry , cascade , monoamine oxidase , transaminase , alkylation , cascade reaction , combinatorial chemistry , monoamine neurotransmitter , enzyme , organic chemistry , catalysis , biochemistry , enantioselective synthesis , serotonin , chromatography , receptor
Herein we report a one‐pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω‐transaminase cascade, allowing access to enantiopure compounds in >99 % ee . We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.
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