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Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole‐Cell Biocatalyst Containing an ( S )‐Imine Reductase
Author(s) -
Leipold Friedemann,
Hussain Shahed,
Ghislieri Diego,
Turner Nicholas J.
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300539
Subject(s) - imine , iminium , biocatalysis , enantioselective synthesis , chemistry , combinatorial chemistry , organocatalysis , catalysis , stereochemistry , organic chemistry , reaction mechanism
Biocatalytic imine reduction: A whole‐cell recombinant E. coli system, producing an ( S )‐selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This biocatalyst is used for the enantioselective reduction of a broad range of substrates such as dihydroisoquinolines and dihydro‐β‐carbolines as well as iminium ions.