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Access to Alternative Regioisomers for Palladium‐Catalysed Direct Arylations of (Benzo)thiophenes
Author(s) -
Yuan Kedong,
Doucet Henri
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300533
Subject(s) - structural isomer , palladium , chemistry , organic chemistry , stereochemistry , catalysis , combinatorial chemistry
Take from the rich to give to the poor: An heterogeneous Pd catalyst associated to 10 mol % CuCl allows to arylate at C3 of benzo[ b ]thiophenes using aryl chlorides as the coupling partners, without additional ligands or directing groups. An excellent C3/C2 selectivity was obtained, using electron‐rich, electron‐poor and also sterically encumbered aryl chlorides.