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The First Continuous Flow Hydrogenation of Amides to Amines
Author(s) -
Coetzee Jacorien,
Manyar Haresh G.,
Hardacre Christopher,
ColeHamilton David J.
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300431
Subject(s) - flow chemistry , catalysis , amide , chemistry , continuous flow , combinatorial chemistry , stoichiometry , flow (mathematics) , ruthenium , computer science , throughput , organic chemistry , biochemical engineering , mathematics , engineering , telecommunications , geometry , wireless
Hydrogen goes with the flow: Conversion of amides into amines is usually achieved with stoichiometric amounts of metal hydrides, which generate large amounts of waste. Catalytic hydrogenation represents an environmentally benign alternative for this conversion, whereas flow catalysis allows catalyst separation and high throughput. Here, we combine amide hydrogenation and flow catalysis for the first time.