Premium
Copper(II) Triflate Catalyzed Allylic Arylation of Allylic Alcohols: Direct and Selective Access to C ‐Allylanilines
Author(s) -
Chen Ke,
Chen Houguang Jeremy,
Wong Jonathan,
Yang Jinglei,
Pullarkat Sumod A.
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300408
Subject(s) - allylic rearrangement , trifluoromethanesulfonate , chemistry , regioselectivity , catalysis , amination , cycloaddition , copper , combinatorial chemistry , organic chemistry , medicinal chemistry
Copper(II) triflate was used as a simple and commercially available catalyst in the direct amination of allylic alcohols with anilines to provide C ‐allylanilines. A wide range of functional groups were tolerated under the reaction conditions, and the products were obtained regioselectivity without the need of an activator. A detailed mechanistic investigation was undertaken. The efficacy of this protocol was demonstrated in the conversion of the 2‐allylanilines into substituted quinolines through an oxidative cycloaddition reaction.