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Simple Organic Molecules as Catalysts for the Enantioselective Synthesis of Amines and Alcohols
Author(s) -
Cui Yi,
Kobayashi Shū
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300380
Subject(s) - enantioselective synthesis , catalysis , reagent , chemistry , amine gas treating , selectivity , combinatorial chemistry , organic synthesis , organic chemistry , alcohol , boron
Valiant catalysis: Hoveyda et al. have developed a set of catalysts derived from valine for enantioselective syntheses. Reagents are inexpensive, allyl additions are scalable, harsh conditions are avoided, and reactions can be performed with 0.25 mol % catalyst in under 6 h at room temperature. The efficiency, economy, selectivity, and simplicity of the transformations and the range of boron reagents look to have sustained impact on future progress in amine and alcohol syntheses.