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Nickel‐Catalysed Reductive Amination with Hydrosilanes
Author(s) -
Zheng Jianxia,
Roisnel Thierry,
Darcel Christophe,
Sortais JeanBaptiste
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300338
Subject(s) - hydrosilylation , reductive amination , nickel , silylation , amination , catalysis , chemistry , combinatorial chemistry , organic chemistry , computer science
That's just silyl! Selective nickel‐catalyzed reductive amination of aldehydes under hydrosilylation conditions is achieved by using a one pot, two step procedure. By using an in situ‐generated catalyst (5 mol %) from Ni(OAc) 2 and tricyclohexylphosphine with tetramethyldisiloxane (TMDS) as the hydrosilane at 70 °C, the corresponding secondary amines were obtained in moderate to good isolated yields.
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