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Asymmetric Aldol Reaction of Glyoxal Catalyzed by Diarylprolinol
Author(s) -
Hayashi Yujiro,
Kojima Masahiro
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201300247
Subject(s) - glyoxal , aldol reaction , chemistry , aldehyde , yield (engineering) , catalysis , selectivity , organic chemistry , trifluoromethyl , materials science , alkyl , metallurgy
All selection should be this ee asy: The direct asymmetric aldol reaction of commercial aqueous glyoxal is catalyzed by trifluoromethyl‐substituted diarylprolinol 1 to afford a β‐formyl‐β‐hydroxy‐α‐substituted aldehyde in good yield with excellent anti selectivity and excellent enantioselectivity.