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Asymmetric Copper‐catalyzed 1,4‐Additions and Allylic Substitutions with Nucleophiles Formed by the Hydrometalation of Alkenes
Author(s) -
Šebesta Radovan
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200926
Subject(s) - nucleophile , allylic rearrangement , enantioselective synthesis , chemistry , catalysis , copper , zirconium , boron , organic chemistry , alkene , combinatorial chemistry
From pots and pans to hydrometalation: Hydrometalation reactions using boron and zirconium hydrides transform alkenes into useful alkylmetal nucleophiles. These nucleophiles can be employed in the copper‐catalyzed 1,4‐additions to α,β‐unsaturated carbonyl compounds or allylic substitutions. Important advances have been achieved recently, which enabled also enantioselective versions of these transformations.