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Lipase‐Catalyzed Stereoselective Cross‐Aldol Reaction Promoted by Water
Author(s) -
Xie ZongBo,
Wang Na,
Zhou LongHua,
Wan Fang,
He Ting,
Le ZhangGao,
Yu XiaoQi
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200890
Subject(s) - aldol reaction , stereoselectivity , lipase , chemistry , catalysis , organic chemistry , pancreatic lipase , enzyme
PPL, lipase from porcine pancreas, is first reported to catalyze direct asymmetric aldol reactions between aromatic aldehydes and cyclic ketones. More importantly, the catalytic activity of PPL was greatly promoted by a small quantity of water at 37 °C. A wide range of aromatic aldehydes reacted with cyclic ketones to provide the corresponding aldol products with high yields (up to 99 %) and moderate to good stereoselectivity (up to 90 % ee and 99:1 dr ).