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Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence
Author(s) -
Fink Michael J.,
Schön Michael,
Rudroff Florian,
Schnürch Michael,
Mihovilovic Marko D.
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200753
Subject(s) - flow chemistry , continuous flow , sequence (biology) , computer science , chemistry , combinatorial chemistry , stereoselectivity , epimer , catalysis , biochemical engineering , organic chemistry , engineering , biochemistry
Smart catalysis cuts it short: Natural ( S,S )‐ Aerangis lactone and its epimer are synthesized with excellent optical purity by using in‐line hyphenation of continuous flow reactors and batch biotransformations. Optimization of the reaction steps and engineering of the reactor interfaces leads to a simple and efficient setup, which demonstrates how multistep syntheses can be streamlined into a single‐operation protocol.