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Iron‐Catalyzed Synthesis of Cyclopropyl Halides
Author(s) -
Grupe Sabine,
Jacobi von Wangelin Axel
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200740
Subject(s) - halogenation , chemistry , cycloaddition , combinatorial chemistry , catalysis , halide , alkyl , ring (chemistry) , organic chemistry
Under a halo: Selective iron‐catalyzed hydrodehalogenations of dibromo‐ and dichlorocyclopropanes are effectively realized with t BuMgCl as the reductant. The reactions proceed under mild conditions and exhibit superior selectivities to iron‐free protocols, as no allenes are formed. The sequential combination of base‐mediated dihalocyclopropanation and this mono‐dehalogenation provides straightforward access to substituted monohalocyclopropanes.