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Substrate Recognition and Regioselective Catalysis with Complexes Bearing NR,NH‐NHC Ligands
Author(s) -
Hahn F. Ekkehardt
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200567
Subject(s) - carbene , chemistry , catalysis , regioselectivity , hydrogen bond , substrate (aquarium) , ligand (biochemistry) , combinatorial chemistry , stereochemistry , polymer chemistry , photochemistry , molecule , organic chemistry , biochemistry , oceanography , receptor , geology
Complexes bearing “protic” N‐heterocyclic carbene (NHC) ligands (NR,NH‐NHCs) have been shown to use the NH group of the NHC ligand for the formation of hydrogen bonds to selected substrates. This type of hydrogen bond can be used for substrate recognition, selection, and orientation. In contrast to related systems, the hydrogen bond donor and thus the molecular recognition unit is located in proximity to the metal center. This concept article discusses major strategies for the preparation of complexes bearing protic NHC ligands and their potential applications.