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Palladium‐Based Nanocatalyst for One‐Pot Synthesis of Polysubstituted Quinolines
Author(s) -
Chen Benjamin Wei Jie,
Chng Leng Leng,
Yang Jun,
Wei Yifeng,
Yang Jinhua,
Ying Jackie Y.
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200496
Subject(s) - catalysis , palladium , chemistry , ketone , tandem , alcohol , one pot synthesis , alkylation , nanoparticle , combinatorial chemistry , organic chemistry , primary (astronomy) , reaction conditions , materials science , nanotechnology , physics , astronomy , composite material
The synthesis of quinolines has been achieved through a one‐pot, two‐step tandem reaction catalyzed with AgPd alloy nanoparticles supported on carbon. AgPd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α‐alkylated ketones under an Ar flow. These are reacted with 2‐aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.