Palladium‐Based Nanocatalyst for One‐Pot Synthesis of Polysubstituted Quinolines | Zendy

Chen Benjamin Wei Jie | Zendy; Chng Leng Leng | Zendy; Yang Jun | Zendy; Wei Yifeng | Zendy; Yang Jinhua | Zendy; Ying Jackie Y. | Zendy

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Palladium‐Based Nanocatalyst for One‐Pot Synthesis of Polysubstituted Quinolines

Author(s) -

Chen Benjamin Wei Jie,

Chng Leng Leng,

Yang Jun,

Wei Yifeng,

Yang Jinhua,

Ying Jackie Y.

Publication year - 2013

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201200496

Subject(s) - catalysis , palladium , chemistry , ketone , tandem , alcohol , one pot synthesis , alkylation , nanoparticle , combinatorial chemistry , organic chemistry , primary (astronomy) , reaction conditions , materials science , nanotechnology , physics , astronomy , composite material

The synthesis of quinolines has been achieved through a one‐pot, two‐step tandem reaction catalyzed with AgPd alloy nanoparticles supported on carbon. AgPd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α‐alkylated ketones under an Ar flow. These are reacted with 2‐aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.

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