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Direct Amidation of Aldehydes with Primary Amines under Mild Conditions Catalyzed by Diolefin‐Amine–Rh I Complexes
Author(s) -
RodríguezLugo Rafael E.,
Trincado Mónica,
Grützmacher Hansjörg
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200495
Subject(s) - amine gas treating , rhodium , chemistry , catalysis , primary (astronomy) , organic chemistry , medicinal chemistry , physics , astronomy
Rhodium teaches toleration: The diolefin‐amine–Rh I complex [Rh(OTf)(trop 2 NH)(PPh 3 )] (see scheme) is an effective pre‐catalyst for the amidation of a wide range of aldehydes with primary amines. The corresponding amides are obtained in good‐to‐excellent yields under very mild reactions conditions and a variety of functional groups are tolerated.