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Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds
Author(s) -
Gomez Catherine,
Betzer JeanFrançois,
Voituriez Arnaud,
Marinetti Angela
Publication year - 2013
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200442
Subject(s) - organocatalysis , intramolecular force , phosphine , combinatorial chemistry , chemistry , biochemical engineering , computer science , organic chemistry , catalysis , enantioselective synthesis , engineering
During the last few years, synthetic methods based on phosphine organocatalysis have experienced extremely fast developments. This short overview is intended to demonstrate that these methods can afford suitable tools for the constitution of either focused or diversity‐oriented‐synthesis (DOS) inspired libraries of small molecules for biological screening. It also reports selected examples where these organocatalytic methods have been used conveniently as key steps in the formal or total synthesis of complex natural products. Especially, synthetic applications of the inter‐ and intramolecular cyclizations of unsaturated substrates have been considered in this review.