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Directed Evolution of the Enzyme Monoamine Oxidase (MAO‐N): Highly Efficient Chemo‐enzymatic Deracemisation of the Alkaloid (±)‐Crispine A
Author(s) -
Rowles Ian,
Malone Kirk J.,
Etchells Laura L.,
Willies Simon C.,
Turner Nicholas J.
Publication year - 2012
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200202
Subject(s) - alkaloid , monoamine oxidase , enzyme , chemistry , combinatorial chemistry , computer science , stereochemistry , organic chemistry
Crispine, at the double! Modification of the active site of the enzyme monoamine oxidase (MAO‐N) allows the efficient deracemisation of the alkaloid crispine A. Microwave‐enhanced chemical synthesis results in the rapid production of the racemic compound. Combining both techniques greatly shortens the time required for the synthesis of ( R )‐crispine A.