Premium
Modular Three‐Component Organocatalytic Synthesis of 3,4‐Disubstituted Pyrroles by a One‐Pot Domino Reaction
Author(s) -
MartínSantos Cecilia,
JaravaBarrera Carlos,
Parra Alejandro,
Esteban Francisco,
NavarroRanninger Carmen,
Alemán José
Publication year - 2012
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200104
Subject(s) - enamine , domino , adduct , organocatalysis , pyrrole , cascade reaction , chemistry , catalysis , amine gas treating , component (thermodynamics) , combinatorial chemistry , michael reaction , reaction conditions , organic chemistry , enantioselective synthesis , physics , thermodynamics
Pull the trigger! The use of ( Z )‐β,β‐bromo‐nitroalkenes under enamine catalysis provides the 1,4‐Michael adduct intermediate, which upon treatment with the desired amine (R 3 NH 2 ) triggers the domino reaction to provide the final 3,4‐disubstituted pyrrole derivatives.