Directed Evolution of P 450 BM 3 into a  p ‐Xylene Hydroxylase | Zendy

Dennig Alexander | Zendy; Marienhagen Jan | Zendy; Ruff Anna Joelle | Zendy; Guddat Lukas | Zendy; Schwaneberg Ulrich | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Directed Evolution of P 450 BM 3 into a p ‐Xylene Hydroxylase

Author(s) -

Dennig Alexander,

Marienhagen Jan,

Ruff Anna Joelle,

Guddat Lukas,

Schwaneberg Ulrich

Publication year - 2012

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201200092

Subject(s) - reuse , catalysis , enzyme kinetics , production (economics) , selectivity , chemistry , enzyme , xylene , combinatorial chemistry , computer science , organic chemistry , active site , toluene , engineering , microeconomics , waste management , economics

Reduce, reuse, reengineer! 2,5‐Dimethylphenol is of high interest for the production of temperature stable polymers (>500 K) and as a building block for “next‐generation” plastics. The presented reengineered P 450 BM 3 variant (R 47 S/Y 51 W/I 401 M) has a good catalytic activity ( k cat =1950 min −1 ), excellent coupling efficiency (66 %), and selectivity (>98 %) for 2,5‐dimethylphenol production.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research