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Laccase‐catalyzed 3‐Arylation of 3‐Substituted Oxindoles
Author(s) -
Pietruszka Jörg,
Wang Chuan
Publication year - 2012
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201200051
Subject(s) - laccase , catalysis , chemistry , combinatorial chemistry , organic chemistry , enzyme
Hookup with an enzyme: A laccasecatalyzed arylation between various N ‐Boc‐protected oxindoles and catechols using atmospheric oxygen as oxidant has been developed that can form 3,3‐disubstitued oxindoles with complete regioselectivity. After conversion to their methylated derivatives the products were isolated in moderate to high yields (52–87 %) over two steps.