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Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β‐Functionalization of Aldehydes
Author(s) -
Xiao Jian
Publication year - 2012
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201100488
Subject(s) - enantioselective synthesis , enamine , iminium , chemistry , catalysis , aldehyde , organocatalysis , nucleophile , surface modification , organic chemistry , amine gas treating , stereoselectivity , combinatorial chemistry
Jekyll and aldeHyde: The oxidation of enamines to iminium species by 2‐iodoxybenzoic acid (IBX) or 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ) catalyzed by a chiral secondary amine catalyst enabled the unprecedented enantioselective β‐functionalization of aldehydes with various nucleophiles in high stereoselectivity.