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C1‐Substituted N ‐Alkyl Tetrahydroisoquinoline Derivatives through V‐Catalyzed Oxidative Coupling
Author(s) -
Jones Kevin M.,
Karier Pol,
Klussmann Martin
Publication year - 2012
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201100324
Subject(s) - alkyl , nucleophile , chemistry , catalysis , oxidative coupling of methane , combinatorial chemistry , organic synthesis , tetrahydroisoquinoline , coupling (piping) , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
In the THIQ of it: N ‐Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m ‐CPBA and [VO(acac) 2 ]. This method has been applied to the synthesis of the opioid methopholine.