Premium
A Palladium‐Catalyzed Multicascade Reaction: Facile Low‐Temperature Hydrogenolysis of Activated Nitriles and Related Functional Groups
Author(s) -
Yap Aaron J.,
Chan Bun,
Yuen Alexander K. L.,
Ward Antony J.,
Masters Anthony F.,
Maschmeyer Thomas
Publication year - 2011
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201100076
Subject(s) - hydrogenolysis , palladium , catalysis , chemistry , aryl , ab initio , functional group , organic chemistry , combinatorial chemistry , polymer , alkyl
The facile hydrogenolysis of various nitriles, imines, and amines over Pd/C has been achieved by using straightforward and relatively mild conditions. Substrates that contain an aryl group adjacent to the nitrogen‐containing functionality were hydrogenolyzed most effectively. The stabilization of the proposed η 2 ‐coordinated palladium intermediate by this group was partly responsible for this observation and is borne out by ab initio calculations.