Palladium‐Catalyzed Direct Benzylation of Xanthines | Zendy

Sahnoun Sophian | Zendy; Messaoudi Samir | Zendy; Brion JeanDaniel | Zendy; Alami Mouâd | Zendy

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Palladium‐Catalyzed Direct Benzylation of Xanthines

Author(s) -

Sahnoun Sophian,

Messaoudi Samir,

Brion JeanDaniel,

Alami Mouâd

Publication year - 2011

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201000439

Subject(s) - palladium , catalysis , chemistry , base (topology) , organic chemistry , combinatorial chemistry , medicinal chemistry , mathematical analysis , mathematics

An efficient and versatile synthetic palladium‐catalyzed sp 2 CH bond activation approach for the preparation of a series of C8‐benzyl xanthines has been developed using benzyl chlorides as coupling partners. The reactions take place rapidly in 1,4‐dioxane and proceed in the presence of [PdCl 2 (MeCN) 2 ]/P( o ‐tolyl) 3 as a catalyst system and Cs 2 CO 3 as a base to afford good to excellent yields of the corresponding C8‐benzylated xanthines of biological interest.

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