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Dual Catalysis in Highly Enantioselective Multicomponent Reaction with Water: An Efficient Approach to Chiral β‐Amino‐α‐Hydroxy Acid Derivatives
Author(s) -
Qian Yu,
Jing Changcheng,
Shi Taoda,
Ji Jingjing,
Tang Min,
Zhou Jing,
Zhai Changwei,
Hu Wenhao
Publication year - 2011
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000437
Subject(s) - enantioselective synthesis , phosphoric acid , diazo , yield (engineering) , chemistry , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , materials science , metallurgy
Dual to the death: Catalyzed by [Rh 2 (OAc) 4 ] and a chiral phosphoric acid, an enantioselective symmetric three‐component reaction of diazo compounds with imines and water is reported to give β‐amino‐α‐hydroxy acid derivatives in good yield (up to 86 %) with excellent diastereoselectivity (up to 98:2 d.r.) and enantioselectivity (up to 97 % ee ).