Dual Catalysis in Highly Enantioselective Multicomponent Reaction with Water: An Efficient Approach to Chiral β‐Amino‐α‐Hydroxy Acid Derivatives | Zendy

Qian Yu | Zendy; Jing Changcheng | Zendy; Shi Taoda | Zendy; Ji Jingjing | Zendy; Tang Min | Zendy; Zhou Jing | Zendy; Zhai Changwei | Zendy; Hu Wenhao | Zendy

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Dual Catalysis in Highly Enantioselective Multicomponent Reaction with Water: An Efficient Approach to Chiral β‐Amino‐α‐Hydroxy Acid Derivatives

Author(s) -

Qian Yu,

Jing Changcheng,

Shi Taoda,

Ji Jingjing,

Tang Min,

Zhou Jing,

Zhai Changwei,

Hu Wenhao

Publication year - 2011

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201000437

Subject(s) - enantioselective synthesis , phosphoric acid , diazo , yield (engineering) , chemistry , catalysis , organocatalysis , organic chemistry , combinatorial chemistry , materials science , metallurgy

Dual to the death: Catalyzed by [Rh 2 (OAc) 4 ] and a chiral phosphoric acid, an enantioselective symmetric three‐component reaction of diazo compounds with imines and water is reported to give β‐amino‐α‐hydroxy acid derivatives in good yield (up to 86 %) with excellent diastereoselectivity (up to 98:2 d.r.) and enantioselectivity (up to 97 % ee ).

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