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Enantioselective Intramolecular Hydroamination of Secondary Amines Catalyzed by Easily Accessible Ate and Neutral Rare‐Earth Complexes
Author(s) -
Queffelec Clémence,
Boeda Fabien,
Pouilhès Annie,
Meddour Abdelkrim,
Kouklovsky Cyrille,
Hannedouche Jérôme,
Collin Jacqueline,
Schulz Emmanuelle
Publication year - 2011
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000323
Subject(s) - hydroamination , enantioselective synthesis , chemistry , ytterbium , rare earth , enantiomer , yttrium , intramolecular force , catalysis , enantiomeric excess , amine gas treating , iridium , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , doping , mineralogy , oxide , optoelectronics
The magnificent neutral: Secondary amines are cyclized into the corresponding scalemic pyrrolidines and piperidines with in situ‐prepared chiral alkylamido ate and neutral yttrium and ytterbium catalysts. The enantiomeric excess of 83 % ee is the highest reported value for a rare‐earth‐promoted hydroamination of a secondary amine.