Premium
Substituent Effect on Catalytic Activities of [{η 5 ‐Ar 4 C 4 COC(O)Ar}Ru(CO) 2 Cl] in Racemization and DKR of Secondary Alcohols
Author(s) -
Lee Jin Hee,
Kim Namdu,
Kim MahnJoo,
Park Jaiwook
Publication year - 2011
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000304
Subject(s) - racemization , substituent , ruthenium , chemistry , medicinal chemistry , catalysis , kinetic resolution , stereochemistry , organic chemistry , enantioselective synthesis
The derivatives of [{η 5 ‐Ph 4 C 4 COC(O)Ph}Ru(CO) 2 Cl] were synthesized to investigate the substituent effect of the ruthenium complexes on the racemization and the chemoenzymatic dynamic kinetic resolution (DKR) of secondary alcohols, in which the phenyl rings are substituted with several different groups. Derivatives with electron‐donating substituents showed better activities than those with electron‐deficient ones, both in the racemization and in the DKR. The ruthenium complex, [{η 5 ‐Ar 4 C 4 COC(O)Ar}Ru(CO) 2 Cl] (Ar=4‐methoxyphenyl), showed an activity about 14 times higher than that of [{η 5 ‐Ph 4 C 4 COC(O)Ph}Ru(CO) 2 Cl] in the racemization of 1‐phenylethanol.