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Chemoenzymatic One‐Pot Synthesis of both ( R )‐ and ( S )‐Aryl‐1,2‐ethanediols
Author(s) -
Bencze László Csaba,
Paizs Csaba,
Toşa Monica Ioana,
Irimie Florin Dan,
Rétey János
Publication year - 2011
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000295
Subject(s) - aryl , benzofuran , chemistry , thiophene , enantiomer , stereochemistry , chemical synthesis , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , alkyl
Both enantiomers of various 1‐aryl‐1,2‐ethanediols have been prepared in a one‐pot method from the corresponding arylethanones through the combination of chemical and enzymatic reactions. A range of aryl groups, phenyl, 4‐chlorophenyl, benzo[ b ]thiophene‐3‐yl, and benzofuran‐2‐yl, were used. The highly enantiomerically enriched ( R )‐ and ( S )‐1‐aryl‐1,2‐ethanediols were obtained with excellent yields, calculated for the arylethanones.