Chemoenzymatic One‐Pot Synthesis of both ( R )‐ and ( S )‐Aryl‐1,2‐ethanediols | Zendy

Bencze László Csaba | Zendy; Paizs Csaba | Zendy; Toşa Monica Ioana | Zendy; Irimie Florin Dan | Zendy; Rétey János | Zendy

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Chemoenzymatic One‐Pot Synthesis of both ( R )‐ and ( S )‐Aryl‐1,2‐ethanediols

Author(s) -

Bencze László Csaba,

Paizs Csaba,

Toşa Monica Ioana,

Irimie Florin Dan,

Rétey János

Publication year - 2011

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.201000295

Subject(s) - aryl , benzofuran , chemistry , thiophene , enantiomer , stereochemistry , chemical synthesis , combinatorial chemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , alkyl

Both enantiomers of various 1‐aryl‐1,2‐ethanediols have been prepared in a one‐pot method from the corresponding arylethanones through the combination of chemical and enzymatic reactions. A range of aryl groups, phenyl, 4‐chlorophenyl, benzo[ b ]thiophene‐3‐yl, and benzofuran‐2‐yl, were used. The highly enantiomerically enriched ( R )‐ and ( S )‐1‐aryl‐1,2‐ethanediols were obtained with excellent yields, calculated for the arylethanones.

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