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Regioselective Hydroformylation of Styrene Using Rhodium‐Substituted Carbonic Anhydrase
Author(s) -
Jing Qing,
Kazlauskas Romas J.
Publication year - 2010
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000159
Subject(s) - rhodium , hydroformylation , regioselectivity , chemistry , styrene , aldehyde , carbonic anhydrase , catalysis , combinatorial chemistry , organic chemistry , enzyme , copolymer , polymer
CA confidential: Replacing the active‐site zinc in carbonic anhydrase (CA) by rhodium forms a new enzymatic catalyst for cofactor‐free hydroformylation of styrene with syn gas. Unlike free rhodium, this rhodium–protein hybrid, [Rh]–CA, is regioselective (8.4:1) for linear over branched aldehyde product, which is a 40‐fold change in regioselectivity compared to free rhodium.