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Cu Nanoparticles in PEG: A New Recyclable Catalytic System for N ‐Arylation of Amines with Aryl Halides
Author(s) -
Kidwai Mazaahir,
Mishra Neeraj Kumar,
Bhardwaj Saurav,
Jahan Anwar,
Kumar Ajeet,
Mozumdar Subho
Publication year - 2010
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000062
Subject(s) - aryl , polyethylene glycol , iodobenzene , catalysis , peg ratio , halide , nanoparticle , chemistry , combinatorial chemistry , coupling reaction , organic chemistry , materials science , nanotechnology , alkyl , finance , economics
A new protocol for the N ‐arylation of aryl halides with anilines using Cu nanoparticles in polyethylene glycol (PEG) as an efficient and reusable catalytic system has been developed. The reaction did not require any cocatalyst. Various solvents were screened, and PEG 400 provided the best results. The studies showed that the mechanism of catalytic action is dependent on the size of the nanoparticles. The Cu nanoparticles and PEG were recyclable and retained their activity. This newly developed protocol was also found to be suitable for the cross coupling of NH heterocycles with iodobenzene. The present methodology offers several advantages, such as excellent yields, short reaction times, and milder reaction conditions.