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Copper‐Catalyzed Asymmetric β‐Boration of α,β‐Unsaturated Carbonyl Derivatives
Author(s) -
Mantilli Luca,
Mazet Clément
Publication year - 2010
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.201000008
Subject(s) - chemistry , catalysis , copper , ligand (biochemistry) , enantioselective synthesis , transition metal , organic chemistry , combinatorial chemistry , biochemistry , receptor
The β generation: Transition metal‐ catalyzed asymmetric β‐boration of α,β‐ unsaturated carbonyl derivatives has recently received much attention. Although a variety of metals can be used to promote this reaction, copper has recently emerged as the candidate of choice. Given the appropriate chiral ligand and reaction conditions, the challenging β‐boration of β,β‐disubstituted cyclic enones is achieved with excellent yields and enantioselectivities.