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Enantioselective Organocatalytic Strecker Reactions in the Synthesis of α‐Amino Acids
Author(s) -
Martens Jürgen
Publication year - 2010
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.200900301
Subject(s) - enantioselective synthesis , hydrocyanation , strecker amino acid synthesis , organocatalysis , chemistry , catalysis , organic chemistry , selectivity , combinatorial chemistry
Both the classical Strecker three‐ component one‐pot synthesis and the hydrocyanation of preformed imines (modified Strecker reaction) can be made enantioselective, affording optically active α‐amino acids, through the application of suitable organocatalysts. Several new and simple organocatalysts with high selectivity and activity have been introduced recently with the potential to be stable enough for catalyst recovery and immobilization.