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Asymmetric Induction by Chiral Borate Anions in Enantioselective Hydrogenation using a Racemic RhBinap Catalyst
Author(s) -
Chen Dianjun,
Sundararaju Basker,
Krause Rafael,
Klankermayer Jürgen,
Dixneuf Pierre H.,
Leitner Walter
Publication year - 2010
Publication title -
chemcatchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.497
H-Index - 106
eISSN - 1867-3899
pISSN - 1867-3880
DOI - 10.1002/cctc.200900229
Subject(s) - enantiopure drug , enantioselective synthesis , asymmetric hydrogenation , binap , chemistry , asymmetric induction , rhodium , catalysis , ligand (biochemistry) , boron , chiral ligand , medicinal chemistry , organic chemistry , receptor , biochemistry
With a little help from my friend: Combination of the racemic binap ligand with enantiopure bis‐( S )‐binol‐borate anion results in enantioselectivities up to 57 % ee in the rhodium‐catalyzed asymmetric hydrogenation of dimethyl itaconate, which corresponds to 85 % of the asymmetric induction caused by the enantiopure binap ligand.