Asymmetric Induction by Chiral Borate Anions in Enantioselective Hydrogenation using a Racemic RhBinap Catalyst | Zendy

Chen Dianjun | Zendy; Sundararaju Basker | Zendy; Krause Rafael | Zendy; Klankermayer Jürgen | Zendy; Dixneuf Pierre H. | Zendy; Leitner Walter | Zendy

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Asymmetric Induction by Chiral Borate Anions in Enantioselective Hydrogenation using a Racemic RhBinap Catalyst

Author(s) -

Chen Dianjun,

Sundararaju Basker,

Krause Rafael,

Klankermayer Jürgen,

Dixneuf Pierre H.,

Leitner Walter

Publication year - 2010

Publication title -

chemcatchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.497

H-Index - 106

eISSN - 1867-3899

pISSN - 1867-3880

DOI - 10.1002/cctc.200900229

Subject(s) - enantiopure drug , enantioselective synthesis , asymmetric hydrogenation , binap , chemistry , asymmetric induction , rhodium , catalysis , ligand (biochemistry) , boron , chiral ligand , medicinal chemistry , organic chemistry , receptor , biochemistry

With a little help from my friend: Combination of the racemic binap ligand with enantiopure bis‐( S )‐binol‐borate anion results in enantioselectivities up to 57 % ee in the rhodium‐catalyzed asymmetric hydrogenation of dimethyl itaconate, which corresponds to 85 % of the asymmetric induction caused by the enantiopure binap ligand.

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